Hiv invasion of immune cells hiv infects t cells via high affinity interaction between the virion envelope glycoprotein gp120 and the cd4 molecule the infection of t cells is assisted by the t cell co receptor called cxcr4 while hiv infects monocytes by interacting with ccr5 co receptor figure 1. Cellular immunology of hiv infection g p spickett and a g dalgleish author information sattentau q smith a tedder rs clapham p dalgleish a weber j adler mw human immunodeficiency virus hiv infection in the regular sexual partners of homosexual men with aids and persistent generalised lymphadenopathy j med virol 1987 may 22 191 98 wood gs warner nl warnke ra anti leu 3 . Most infants born to human immunodeficiency virus hiv infected women escape hiv infection infants evade infection despite an immature immune system and in the case of breastfeeding prolonged repetitive exposure if infants become infected the course of their infection and response to treatment differs dramatically. Leading experts provide the only comprehensive book examining all aspects of immune response and immune based treatments for hiv infection contributions divided into three sections discuss basic mechanisms immunopathogenesis of hiv infection and immune based therapies. Author information 1department of microbiology and immunology baylor college of medicine houston texas 77030 the goal of finding an effective vaccine against the human immunodeficiency virus hiv is hampered by our uncertainty of the mechanisms responsible for the pathogenesis as well as the lack of knowledge of protective mechanisms
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